Today, URL Pharma was acquired by Takeda for nearly $800M.  The story here in brief is that for hundreds of years, colchicine was used for the treatment of gout and other conditions; it was an effective drug but had to be used carefully. URL invested in the formulation development and clinical studies required for colchicine, and ultimately received FDA approval in 2009. 

Reviewing "The Myth of The Paperless Office" for the New Yorker in 2002, Malcolm Gladwell argued that if the computer had come first, and paper didn't exist, someone would have had to invent it.  Paper, it turns out, is a lot more useful than we typically appreciate.

Every serious study of U.S. infrastructure has reached the same conclusion: More investment is needed -- and fast. But with Sen. Jeff Bingaman's amendment to the highway reauthorization bill, the Senate effectively penalizes states for using innovative infrastructure financing.

How did the financial system accumulate an unprecedented number of risky mortgages?

Efforts to blame the banks for the financial crisis are failing because they are not supported by data. The key fact is that, by 2008, before the crisis, half of the 54 million mortgages in the U.S. financial system were subprime and other low-quality mortgages.

Only overwhelming sanctions leading to Iran’s economic collapse can work, but with Russia and China shielding Iran, such crippling sanctions appear unlikely.

The Federal Reserve has recently begun discussing strategies for reducing its approximately $1.2 trillion of Mortgage Backed Securities (MBS) acquired from Freddie Mac, Fannie Mae and Ginnie Mae during the financial crisis.

In the case of the asset backed securities portfolio that the Fed acquired in support of the Bear Stearns acquisition by JPMorgan Chase the Shadow Financial Regulatory Committee suggested that the Fed disclose the names of counterparties to transactions, how transactions were priced, the quality and extent of collateralization and the current market-to-market values on those assets.