At the NATO summit in Chicago, the much hoped-for deal between the United States and Pakistan to reopen NATO supply routes through Pakistan did not materialize. The experience of the closure and the negotiations has laid bare the changed relationship between the U.S. and Pakistan.

Iran could offer to halt production of 20% enriched uranium in upcoming negotiations. This “concession” would have limited impact on Iran’s ability to quickly produce weapons-grade uranium for one nuclear warhead, however. Iran would still retain the ability to resume 20% enrichment and to produce weapons-grade uranium at a time of its choosing.

The anniversary of Osama bin Laden’s death last week focused attention briefly on the continued threat posed by al Qaeda Central. But what about al Qaeda's franchises elsewhere, like al Shabaab in Somalia? The viability of the threat these groups pose to the U.S. deserves more careful consideration than it has received.

Successfully translating scientific discoveries requires a sense of urgency, which some disease foundations seem to have, and many big pharmas appear to need. Patients waiting expectantly for medical research to produce important new cures are finding bad news almost everywhere they turn.

The new government in Yemen has extracted several of former President Ali Abdullah Saleh’s cronies from the country’s power structure, including demotion of Saleh’s half-brother Mohammed al Ahmar and nephew Tareq Mohammed Saleh, the former heads of the Air Force and Presidential Guard, respectively.

Iran is at the threshold of a nuclear weapons capability. Sanctions, direct action, and diplomatic tools have neither changed Iran’s nuclear policy nor had a visible effect on the enrichment program, including the growing stockpile of 19.75% LEU.

American assistance programs aimed at helping Yemen build and maintain counterterrorism forces will not suffice in the face of a real and growing al Qaeda-affiliated insurgency.

The leadership of the ISI is changing hands at a critical time for both the U.S. and Pakistan.